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Thrush - new medication (Loramyc®)
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Picture of Dr Vinod K Joshi
Posted
Chemotherapy and radiotherapy for the treatment of cancer often cause an irritation of the mucosa (namely the mouth and digestive tract) called mucositis. Among other factors, oral mucositis can in turn facilitate or aggravate infections with yeasts that normally are well controlled by our immune system. These infections are called candidiasis and can be very detrimental to patients’ quality of life and treatment conduct. It is also very important to prevent the infection from disseminating to the rest of the body.

I have been informed of the availability of a new treatment for candidiasis (thrush) specifically designed for head and neck cancer patients. See below:
quote:
Loramyc® is a new treatment with a an innovative delivery system, indicated for treatment of oral thrush (oropharyngeal candidiasis, or OPC) in immunocompromised patients, especially people undergoing chemotherapy and/or radiotherapy.

Loramyc® is a local treatment, in the form of a tasteless tablet that sticks to the upper gum, applied once a day. It is effective enough to treat OPC, while avoiding the increased burden of more pills to swallow and potential side effects to bear with or the several times a day use of a mouthwash. Loramyc® has to be applied after brushing the teeth. It can be administered with food and drinks.

Loramyc® therefore meets the need for a potent, targeted treatment of this localised fungal infection thanks to its innovative muco-adhesive tablet formulation.

Loramyc® was developed by a French speciality pharmaceutical company, BioAlliance Pharma, It is now available in the UK since May 2008 and distributed in Europe by SpeBio, a joint venture of SpePharm and BioAlliance Pharma.

Spepharm UK Ltd.
8A New Yatt Road
Witney
Oxfordshire
OX28 1NZ
www.spepharm.com

Bioalliance Pharma
49, Bd du General Martial Valin
FR 75015 Paris
http://www.bioalliancepharma.com


There have been several discussions about problems with thrush so Loramyc might be a great help but it would be good to hear of members experience with it and if it works for them.

Best wishes

Vinod Coffee


Disclaimer: Please see your own dentist/doctor for a proper diagnosis as my words should not, in any circumstances, be taken as dental/medical advice.

"If you see what is small as it sees itself, and accept what is weak for what strength it has, and use what is dim for the light it gives, then all will go well. This is called Acting Naturally."
Lao-Tsu, Tao Teh King
 
Posts: 3747 | Location: St Luke's Hospital, Bradford and Pinderfields Hospital, Wakefield | Registered: 14 December 2002Reply With QuoteReport This Post
Picture of Cricket
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Hi Dr. Joshi,

I have a question for you. I'm suffering from a terrible mucous problem. (I've read most of the info on mucous on the forum).

Here's my question though, would this medication help with the mucous? I don't have thrush, at least not yet!

Thanks, Cricket
 
Posts: 142 | Location: Chicago, IL | Registered: 01 May 2008Reply With QuoteReport This Post
Picture of Dr Vinod K Joshi
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Hello Cricket

I don't it helps directly with the problem but oral thrush can make the problem feel worse (I think).

Best wishes
Vinod Coffee


Disclaimer: Please see your own dentist/doctor for a proper diagnosis as my words should not, in any circumstances, be taken as dental/medical advice.

"If you see what is small as it sees itself, and accept what is weak for what strength it has, and use what is dim for the light it gives, then all will go well. This is called Acting Naturally."
Lao-Tsu, Tao Teh King
 
Posts: 3747 | Location: St Luke's Hospital, Bradford and Pinderfields Hospital, Wakefield | Registered: 14 December 2002Reply With QuoteReport This Post
Picture of Chelle
Posted Hide Post
i'dalsobe interested to know how effective it is.
2yrs out of treatment and i STILL suffer with oral thrush if i dont have actimel in the morning!


-~*Great spirits have always encountered violent opposition from mediocre minds*~-
...Albert Einstein
 
Posts: 793 | Location: Hastings, UK | Registered: 01 March 2007Reply With QuoteReport This Post
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Hi,
I am trying to get Loramyc here in Ireland, not so easy as it's not approved or released here. Will order as named patient but will be expensive. Over the past few weeks oral thrush has become a big problem for me. I will try the actimel in the mean time.

Ken


Two Year Survivor
 
Posts: 153 | Location: Ireland | Registered: 04 September 2008Reply With QuoteReport This Post
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Hi,
I applied my first Loramyc tablet today inside my mouth at 1pm. It is placed inside top lip above front teeth on the gum. Tablet is round, flat on one side and slightly raised on the other to a point. After a while the tablet changes shape and spreads it self along the gum. Approximately four times it's original size now. No side effects so far and will keep you updated.

PS: Had second check up today since radiotherapy. Another clear one thank god.

All the best

Ken


Two Year Survivor
 
Posts: 153 | Location: Ireland | Registered: 04 September 2008Reply With QuoteReport This Post
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Oh meant to say the slightly pointy side goes against the gum!

Ken


Two Year Survivor
 
Posts: 153 | Location: Ireland | Registered: 04 September 2008Reply With QuoteReport This Post
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Second day with second tablet. No problems, drinking and eating OK. Placed tablet on right side of gum this time. After cleaning my tongue yesterday the thrush has not re-appeared back on my tongue. So looking good and certainly beats using Daktarin oral gel four times a day.

Ken


Two Year Survivor
 
Posts: 153 | Location: Ireland | Registered: 04 September 2008Reply With QuoteReport This Post
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Fifth tablet today. Developed sore throat again yesterday not sure why? Tongue still clear though. Will keep going and see
what happens.

Regards

Ken


Two Year Survivor
 
Posts: 153 | Location: Ireland | Registered: 04 September 2008Reply With QuoteReport This Post
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Tablet number 9 today. Woke up with very dry mouth/throat much more so than usual. Tongue is clear but throat is sore. Will keep going.

Ken


Two Year Survivor
 
Posts: 153 | Location: Ireland | Registered: 04 September 2008Reply With QuoteReport This Post
Picture of Dr Vinod K Joshi
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Hello Kenny

I was told that to help the drug disseminate more effectively, a patient with a dry mouth should occasionally sip some water. Does this apply in your case?

Best wishes

Vinod Coffee


Disclaimer: Please see your own dentist/doctor for a proper diagnosis as my words should not, in any circumstances, be taken as dental/medical advice.

"If you see what is small as it sees itself, and accept what is weak for what strength it has, and use what is dim for the light it gives, then all will go well. This is called Acting Naturally."
Lao-Tsu, Tao Teh King
 
Posts: 3747 | Location: St Luke's Hospital, Bradford and Pinderfields Hospital, Wakefield | Registered: 14 December 2002Reply With QuoteReport This Post
Posted Hide Post
Not really as I drink lots of water during the day. Actually when the tablet is applied inside the mouth it increases saliva production at the front of the mouth.

What I am experiencing is that first thing in the morning my mouth and throat are so dry it takes a good while and lots of liquids to get things moisterized and moving again. This includes being able to talk without sounding so croaky. Seems to be worse since I started taking these tablets.

My tongue is clear but my throat is sore and stings at times during the day. On tablet number 10.

regards

Ken


Two Year Survivor
 
Posts: 153 | Location: Ireland | Registered: 04 September 2008Reply With QuoteReport This Post
Picture of Dr Vinod K Joshi
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Hello Kenny

Your throat is probaby drying out while you sleep. Try sleeping with mouth closed and also sipping a bit of (swishesd) olive oil before bed to allow it to protect the mouth and throat tissues from the drying effect.

Let me know how you get on.

Best wishes
Vinod Coffee


Disclaimer: Please see your own dentist/doctor for a proper diagnosis as my words should not, in any circumstances, be taken as dental/medical advice.

"If you see what is small as it sees itself, and accept what is weak for what strength it has, and use what is dim for the light it gives, then all will go well. This is called Acting Naturally."
Lao-Tsu, Tao Teh King
 
Posts: 3747 | Location: St Luke's Hospital, Bradford and Pinderfields Hospital, Wakefield | Registered: 14 December 2002Reply With QuoteReport This Post
Picture of Mimi McC
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Hi Kenny,

Last spring I had congestion due to allergies and found it difficult to breathe through my nose. While waiting for the allergy pills to kick in, I used Breathe Right strips to keep my mouth shut while sleeping. They work beautifully.

Breathe Right

The ad reads and looks like so much hype and snake bite medicine but despite that, the darn things work! Buy the large size even if you have a small nose - the extra length allows them to stick to your skin better.

Since so many over-the-counter products have different brand names from country to country, Breathe Right may not be the brand name in Ireland but at least you have an idea of what to look for.

And oh yes, you'll look dorky wearing them but it's worth the blow to the ego, not that we have much left after this experience.

Mimi

This message has been edited. Last edited by: Mimi McC,
 
Posts: 593 | Location: Sacramento, California | Registered: 16 January 2008Reply With QuoteReport This Post
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Hi,

I use BioXtra gel at night although I have noticed that it does not stay in my mouth very long now. It dissolves quickly into saliva and I swallow it. I put lavender on my pillow as this helps me to breath through my nose. Sure this will make the blokes laugh but I will try anything if it helps.

I have also been putting some Germoline cream around the openings of my nostrils to try and ease my blocked up and sore inner nose. I am producing more mucus since completing RT and its difficult to clear my nose when blowing it, mucus is very sticky.

I will see if I can get the strips.

Many thanks

Ken


Two Year Survivor
 
Posts: 153 | Location: Ireland | Registered: 04 September 2008Reply With QuoteReport This Post
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